There will be rain on and off throughout the day in New York and on the East Coast on Wednesday, and checking on the latest weather updates as the day progresses will be as crucial to your MLB DFS strategy as anything else with a smaller night slate. But if they play in New York, Jacob deGrom is scheduled to make his return to the city where he won two Cy Young Awards with the Mets. DeGrom won’t be facing his former team, however, with the Rangers playing the Yankees in the Bronx, and after back-to-back injury-plagued seasons with the Rangers, deGrom has a 2.29 ERA over nine starts this year. How should deGrom’s return to New York factor into forming Wednesday MLB DFS picks, and should you hesitate to spend on Yankees like Aaron Judge or Paul Goldschmidt from the MLB DFS player pool?
The Dodgers snapped their four-game losing streak on Tuesday after scoring three runs in the bottom of the 10th inning and they’ll have popular pieces for Wednesday MLB DFS lineups as well. Before locking in any MLB DFS picks for Wednesday, be sure to check out the MLB DFS advice, strategy and projections from SportsLine’s daily Fantasy expert Mike McClure.
McClure is a daily Fantasy pro who has won more than $2 million in his career. And when it comes to daily Fantasy baseball, McClure is at his best. Recognized in the book “Fantasy Football (and Baseball) for Smart People: How to Turn Your Hobby into a Fortune” as a top MLB DFS player, McClure’s proprietary projection model simulates each game 10,000 times, taking factors such as matchups and recent results into account. This allows him to find the best values on every site.
On Tuesday, McClure identified Astros third baseman Isaac Paredes as one of his value plays and one of his top MLB DFS picks on both sites. The result: Paredes went 1-for-4 with a home run and a walk, returning 16 points on DraftKings and 21.7 points on FanDuel. Anybody who included him in their lineups could have been well on the way to a profitable day.
Now, with the 2025 MLB season continuing on Wednesday, McClure has locked in his top MLB daily Fantasy picks for May 21. You can head to SportsLine now to see them.
McClure’s top MLB DFS picks for Wednesday, May 21
One of McClure’s top MLB DFS picks for Wednesday is Phillies third baseman/first baseman Alec Bohm, who is $4,300 on DraftKings and $3,200 on FanDuel for MLB DFS lineups. Bohm went 2-for-5 with an RBI on Tuesday after going 2-for-5 with a home run on Monday in a strong series against the Rockies, who have struggled to get nearly everybody out this season. The Rockies are 8-40, including 2-15 over their last 17 games, and are allowing eight runs per game over their first two contests against the Phillies.
Bohm’s had 97 RBI in back-to-back seasons as a key run producer in the Phillies lineup, and McClure expects more opportunities for him to drive in runs on Wednesday. Carson Palmquist is making just his second MLB start for Colorado and the 24-year-old allowed five runs in four innings against the Diamondbacks on Friday in his debut. Bohm, a right-handed hitter, hit .287 with an .808 OPS against left-handed pitchers like Palmquist last season.
McClure is also rostering Angels shortstop Zach Neto ($4,600 on DraftKings and $3,500 on FanDuel). The 24-year-old enters on a five-game hitting streak with five RBI over that span. Neto, in his third MLB season, is hitting a career-best .278 with an .867 OPS to showcase why he was the No. 13 overall pick in the 2022 MLB Draft. He had 23 home runs and 30 stolen bases last year in his first full MLB season and his OPS is more than 100 points higher this year.
Neto should feel comfortable in the batter’s box on Wednesday against Athletics left-handed pitcher JP Sears. The shortstop is 4-for-7 with a home run in his career against Sears and the right-handed hitter has a career .313 batting average and .912 OPS against LHPs. McClure loves Neto at his price to return value for Wednesday MLB DFS lineups. See McClure’s full MLB DFS player pool right here.
How to set your MLB DFS lineups for May 21, 2025
McClure is also targeting an undervalued player who is set to explode for huge numbers on Wednesday. The stars are aligning for him to return tournament-winning value and he comes at a price that won’t break the bank. You can only see who it is, and get the rest of McClure’s MLB DFS picks, here.
So what are the top MLB DFS picks for Wednesday? Visit SportsLine now to see DFS millionaire Mike McClure’s complete player pool and picks for FanDuel and DraftKings, all from the DFS expert who has won more than $2 million.
This news was originally published on this post .
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