The Friday MLB schedule is loaded with 15 games and all 30 MLB teams scheduled to play. One of the most notable MLB matchups today is Yankees vs. Dodgers in a rematch of last season’s World Series. First pitch from Dodgers Stadium in Los Angeles is scheduled for 10:10 p.m. ET. The Yankees have won nine of their last 10 and are 35-20 overall, while the Dodgers are 34-22 overall and 19-8 at home. Left-hander Max Fried (7-0, 1.29 ERA) is slated to start for New York, and Tony Gonsolin (2-1, 4.68 ERA) is scheduled to start for Los Angeles.
The Yankees are -120 favorites (risk $120 to win $100) on the money line, while the over/under is 9 runs in the latest MLB odds for Friday. Should you back the Yankees or Dodgers when making MLB picks on Friday? Our model says take the Dodgers +1.5 on the run-line. Before making any MLB picks or building any MLB parlay cards, you’ll want to see the MLB predictions and betting advice from SportsLine’s proven computer simulation model. You can also check out our MLB total bases picks and MLB home run picks for Friday.
The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 10 of the 2025 MLB season on a profitable 27-21 run (56%) on top-rated MLB betting picks. Anybody following at sportsbooks and on betting apps could have seen strong returns.
The model has broken down the MLB odds for Friday and just revealed its top picks and MLB player props. Combining the model’s three picks into an MLB parlay at DraftKings Sportsbook would result in a payout of +420 (risk $100 to win $420). New users can even take advantage of the DraftKings promo code offering $300 in bonus bets instantly with a $5 wager.
Here are its best bets for the MLB slate on Friday.
- Rockies vs. Mets over 7.5 runs (-118)
- Mariners ML vs. Twins (-135)
- Dodgers +1.5 vs. Yankees (-162)
- Combine these picks for a shot at a +420 payout (odds subject to change(
Rockies-Mets over 7.5 runs (-118 on DraftKings)
The Rockies are in the midst of a historically bad season, while the Mets have World Series aspirations. Starting pitcher David Peterson (3-2, 2.79 ERA) has been solid in 2025, but his counterpart for Colorado, Kyle Freeland (0-7, 5.86 ERA), has struggled. This is a game that has the potential to be one of the highest scoring games on the slate, despite its relatively low over/under of 7.5 runs. The model is projecting 9.6 total runs in this game, with the over hitting in 68.5% of computer simulations.
Seattle Mariners money line (-135) vs. Minnesota Twins
Neither team in this matchup has been playing particularly well of late, with Minnesota dropping three of its last four and Seattle losing four of its last five games. The Mariners have a significant advantage at starting pitcher with Bryan Woo (5-2, 2.40 ERA, 0.93 WHIP) on the mound. SportsLine’s model is projecting a final score of 4.5-3.7 in Seattle’s favor with the Mariners winning in 65.3% of computer simulation.
Los Angeles Dodgers +1.5 on the run line vs. New York Yankees (-162)
This is the marquee matchup on the Friday MLB schedule. This game will be the first meeting between these teams since the 2024 World Series, and both teams look primed to be championship contenders again in 2025. On paper, the Yankees have an advantage at starting pitcher, where projected starter Max Fried has emerged as a Cy Young contender. That said, the model is expecting this to be a very tight game with a projected final score of 4.9-4.6 in New York’s favor, with the Dodgers covering in 65% of computer simulations.
This line is also priced at -153 on FanDuel, where new users can take advantage of the FanDuel promo code offering $200 in bonus bets with a winning $5 wager.
Want more MLB picks for today?
You’ve seen some of the model’s MLB best bets for Friday. Now, get run line, total and money-line picks for every game here, all from the model that’s simulated every game 10,000 times.
Also at SportsLine:
You can also see today’s top MLB picks from expert Matt Severance, who’s on a sizzling 126-65 roll on his last 191 MLB picks. Visit SportsLine to see his best plays for today, all from the expert who’s up more than 18 units.
This news was originally published on this post .
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