The 6-seed Detroit Pistons have the 3-seed New York Knicks coming into town for a crucial Game 6 matchup on Thursday in the 2025 NBA playoffs. The Knicks went into Game 5 on a two-game win streak and a 3-1 lead. They weren’t able to close things out, as the Pistons came away with a 106-103 victory. The winner of this series will advance to play the Boston Celtics in the Eastern Conference semifinals.
Tipoff is at 7:30 p.m. ET from Little Caesars Arena in Detroit. Detroit is a 1.5-point favorite in the latest Knicks vs. Pistons odds from DraftKings Sportsbook, while the over/under for total points is 212.5. Detroit is listed at -122 on the money line (risk $122 to win $100), with New York priced at +102 (risk $100 to win $102). Before locking in any Pistons vs. Knicks picks, make sure to check out the NBA predictions and betting advice from the SportsLine Projection Model.
The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters the second full week of the 2025 NBA playoffs on a sizzling 156-116 roll on all top-rated NBA picks dating back to last season, returning nearly $4,000. It is also 22-11 (67%) on top-rated NBA against-the-spread picks this season. Anyone following at sportsbooks and on betting apps could have seen huge returns.
Now, the model has simulated Pistons vs. Knicks 10,000 times and just revealed its coveted NBA picks and betting predictions. You can head to SportsLine now to see the model’s picks. Here are several NBA odds and NBA betting lines for Pistons vs. Knicks:
- Knicks vs. Pistons spread: Detroit -1.4 at DraftKings Sportsbook
- Knicks vs. Pistons over/under: 212.5 points
- Knicks vs. Pistons money line: Detroit -122, New York +102
- NYK: Knicks are 43-43-1 against the spread this season
- DET: Pistons are 44-40-3 against the spread this season
- Knicks vs. Pistons picks: See picks at SportsLine
- Knicks vs. Pistons streaming: FuboTV (Try for free)
Why the Knicks can cover
Guard Jalen Brunson is constantly the main ball handler and playmaker for the Knicks. Brunson knows how to draw contact at the rim and has the ability to space the floor. He leads the team in points (29.8) and assists (8.4) thus far in the playoffs. The Villanova product has logged 30-plus points in four of the five games this series.
Forward OG Anunoby gives this team a two-way threat in the frontcourt. In this series, Anunoby leads the team in steals (2.4) to go along with 16.4 points and 4.8 rebounds per contest. He’s scored at least 19 points in three of the five games this postseason. In his last outing, the 27-year-old had 19 points, eight boards, and three blocks. See which team to back at SportsLine.
Why the Pistons can cover
Guard Cade Cunningham plays the go-to role offensively for the Pistons. Cunningham owns a diverse scoring plan with great vision as a facilitator. He’s third in the league in assists (8.8) this postseason with team-highs in points (25.4) and steals (1.6). In the Game 5 victory, the 23-year-old finished with 24 points, eight rebounds, and eight assists.
Forward Tobias Harris has been a solid scorer on the perimeter who can put the ball on the deck. In the 2025 NBA playoffs, Harris logs 16 points, 8.2 rebounds, 1.4 blocks, and makes 45% of his 3-point attempts. The Tennessee product has scored 15-plus points in four of his last five games. On Tuesday, Harris finished with 17 points, eight rebounds, four blocks, two steals, and made three 3-pointers. See which team to back at SportsLine.
How to make Knicks vs. Pistons picks
SportsLine’s model has simulated Knicks vs. Pistons and is leaning Over the total, projecting 213 combined points. The model also says one side of the spread has all of the value. You can head to SportsLine to see the model’s NBA picks.
So who wins Knicks vs. Pistons, and which side of the spread has all of the value? Visit SportsLine now to see which side of the Pistons vs. Knicks spread to back, all from the model that has returned well over $10,000 on top-rated NBA picks, and find out.
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