The San Diego Padres will meet the Los Angeles Dodgers in the second matchup of a four-game series in a key National League West Division matchup on Tuesday night. The Dodgers earned a 6-3 win in Monday’s series opener. San Diego is expected to start right-hander Randy Vasquez (3-4, 3.57 ERA), while Los Angeles will give the ball to left-hander Jack Dreyer (2-2, 2.78 ERA).
First pitch from Dodger Stadium in Los Angeles is set for 10:10 p.m. ET. Los Angeles is -215 on the money line (risk $215 to win $100) in the latest Padres vs. Dodgers odds from FanDuel Sportsbook, while San Diego is a +180 underdog (risk $100 to win $180). The over/under for total runs scored is 10. Los Angeles’ Shohei Ohtani is at +158 to hit a home run, while San Diego’s Manny Machado is +120 to record an RBI.
The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 13 of the 2025 MLB season on a 37-30 run on top-rated MLB money-line betting picks. Anybody following at sportsbooks and on betting apps, or new users taking advantage of the latest DraftKings promo code or Fanatics Sportsbook promo code could have seen strong returns.
Here are the model’s three best bets for Padres vs. Dodgers (odds subject to change):
- Padres ML (+180)
- Padres run line +1.5 (-114)
- Gavin Sheets over 0.5 total bases (-165)
Padres to win (+180)
San Diego will look to turn around its recent fortunes and close to within three games of the first-place Dodgers. The Padres enter the game with the third-best ERA in the National League at 3.55, while Los Angeles is 11th with a 4.17 ERA. The model favors San Diego, which has a money line probability of over 40%, giving this a B rating. FanDuel is one of the books with a +180 price on the Padres, and new users can unlock even more value with a FanDuel promo code:
Padres run line +1.5 (-114)
The model has simulated the game 10,000 times. It suggests San Diego will be able to cover the run line, and has the Dodgers winning the game by an average score of 4.9 to 4.6, with San Diego covering well over 60% of the time, making it the better value. The model gives this a B rating. The Dodgers are 26-12 on their home field in 2025, while San Diego is 18-20 on the road.
If you want even more MLB picks, SportsLine’s top MLB expert, Matt Severance, is heating up. Get his best bets for Tuesday, all from the expert who is 163-85 on his last 248 MLB picks (+21).
Gavin Sheets over 0.5 total bases (-165)
Sheets, a second round draft pick by the White Sox in 2017, is hitting .267 with 10 doubles, one triple, 12 homers and 40 RBI in 68 games this season. He is in the midst of a seven-game hitting streak. In Saturday’s 8-7 loss to Arizona, he was 3-for-3 with a double, homer and one RBI. He doubled in Monday’s loss to the Dodgers. He had hits in all three games against the Dodgers in last week’s series in San Diego.
The model is projecting 1.5 total bases for Sheets, and gives this prop a five-star rating. Sheets has achieved five over games in his last five with an impressive average of 2.6 total bases per game. bet365 has this line at -160, and new users can utilize the latest bet365 bonus code if they want even more bang for their buck:
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