The Cleveland Guardians (40-39) will host the St. Louis Cardinals (44-38) to begin a three-game series on Friday. The Guardians fell 6-0 to the Toronto Blue Jays on Thursday. Meanwhile, St. Louis is on a two-game skid, losing 3-0 to the Chicago Cubs one day ago. Sonny Gray (7-2, 3.72 ERA) will start for the Cardinals, while Luis Ortiz (4-8, 4.30 ERA) will take on the mound for Cleveland.
First pitch from Progressive Field in Cleveland is set for 7:10 p.m. ET. St. Louis is -131 on the money line (risk $131 to win $100) in the latest Cardinals vs. Guardians odds from DraftKings Sportsbook, while Cleveland is a +110 underdog (risk $100 to win $110). The over/under for total runs scored is 8.5. Before making any Cardinals vs. Guardians picks, be sure to see the MLB predictions from SportsLine’s proven model.
The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 14 of the 2025 MLB season on a profitable 41-32 run on top-rated MLB picks. It has excelled making home run prop picks this season, returning more than 22 units of profit. Anybody following at sportsbooks and on betting apps could have seen strong returns, especially when paired with the latest BetMGM promo code and FanDuel promo code, just to name a few. Also be sure to see our top MLB prop picks and MLB home run picks for Friday, along with our top MLB parlay.
Here are the model’s three best bets for Cardinals vs. Guardians on Friday:
- Brendan Donovan Under 1.5 hits (-215)
- Steven Kwan 1+ Singles (-170)
- Luis Ortiz Over 4.5 Strikeouts (-115)
Brendan Donovan Under 1.5 hits (-215)
Donovan enters this game hitting .239 with 17 hits in June. The 28-year-old has tallied fewer than two hits in six of the last seven games. He’s gone under in the market total in four of his past five matchups. The model projects 1.1 hits in this contest for Donovan.
If you want even more MLB picks, SportsLine MLB expert, Bruce Marshall, is heating up. Get his best bets for Friday, all from the expert who is 23-17-1 on his last 41 MLB picks (+834).
Steven Kwan 1+ Singles (-170)
Kwan is currently second on the team in batting average (.302) and hits (90). He has recorded a base hit in three of his past six matchups, tallying multiple hits in every outing. On June 24 against the Blue Jays, Kwan went 2-of-4 with two singles.
You’ve now seen the two best bets for Blue Jays vs. Guardians on Friday. Now, get picks for every single game from the model that enters Week 14 of the 2025 MLB season on a 41-32 run on top-rated MLB run-line picks.
Luis Ortiz Over 4.5 strikeouts (-115)
Ortiz has racked up 90 K’s this season for Cleveland. The 26-year-old has piled up at least five strikeouts in five straight games. The model projects him to throw 5.3 K’s in this affair. In his last outing, Ortiz tied his season-best with 10 strikeouts. New users can use the latest FanDuel promo code, which offers $150 in bonus bets if your first bet of $5 or more wins.
This news was originally published on this post .
About the author
Reserve QBs to start as Redblacks host Argonauts
Jun 6, 2025; Montreal, Quebec, Canada; Toronto Argonauts quarterback Nick Arbuckle (4) throws a pass during the first half against the Montreal Alouettes at Percival-Molson stadium. Mandatory Credit: Eric Bolte-Imagn Images Two squads who have their primary quarterbacks ailing and just one combined victory this season square off Sunday night when the Toronto Argonauts visit the Ottawa Redblacks. On the final injury report of the week, the Argonauts announced that 2023 Most Outstanding Player Chad Kelly will not make his season debut. Kelly broke the tibia and fibula in his right leg last November in the East Final at Montreal and missed the following week's victorious Grey Cup contest over the Winnipeg Blue Bombers. "Definitely not this week, definitely not next week. I'm hoping (Kelly will return) after the bye," Argonauts coach Ryan Dinwiddie told TSN. "He's getting better but […]
Naz Reid agrees to new five-year, $125 million deal to stay with Timberwolves: Report
Naz Reid has signed a new five-year, $125 million contract to stay with the Minnesota Timberwolves, according to ESPN's Sham Charania.Reid had the choice to exercise a $15 million player option to stay with the Timberwolves. Instead, he has agreed to a deal to keep him with Minnesota long-term. Per Charania, the new contract also includes a new player option.After winning the NBA’s Sixth Man of the Year award after a breakout 2023-24 campaign, the 6-foot-9, 264-pound Reid authored an impressive encore, averaging 14.2 points, 6.0 rebounds and 2.3 assists in 27.5 minutes per game, all career highs, as an integral frontcourt contributor for a Wolves team that made its second straight run to the Western Conference finals.The sixth-year pro has turned into one of the NBA’s premier reserves, serving as a high-volume, high-efficiency stretch big who has fit snugly […]
Hosting RSL, Sporting KC out to build on improbable win
Jun 25, 2025; Kansas City, Kansas, USA; Sporting Kansas City forward Dejan Joveljic (9) is carried off the field after getting injured scoring the go ahead goal in the second half against Charlotte FC at Children's Mercy Park. Mandatory Credit: Peter Aiken-Imagn Images Could Wednesday night have been the pivot on which Sporting Kansas City's season turns? Down 1-0 at home in stoppage time against Charlotte FC, Sporting KC scored twice in a four-minute span to turn a near-certain defeat into an exhilarating 2-1 win. The improbable victory gave the team three unexpected points to possibly start a playoff push. Sporting KC will try to build on that dramatic result Saturday night when they face Real Salt Lake in Kansas City, Kan. Interim coach Kerry Zavagnin wasn't surprised that his team figured out a way to win a game that […]
Desperate FC Dallas welcomes surging San Diego FC
Jun 25, 2025; Vancouver, British Columbia, CAN; San Diego FC forward Milan Iloski (32) celebrates scoring during the first half against the Vancouver Whitecaps at BC Place. Mandatory Credit: Anne-Marie Sorvin-Imagn Images San Diego FC looks to strengthen its hold atop the Western Conference and complete the season sweep over FC Dallas when the two teams square off on Saturday in Frisco, Texas. San Diego (11-5-3, 36 points) beat Vancouver 5-3 on Wednesday to leapfrog the host Whitecaps and claim first place in the West. Milan Iloski scored a team-record four goals in his first MLS start -- three in a nine-minute span late in the first half -- as San Diego won for the third straight time in MLS play. Iloski, a 25-year-old native of Escondido, California, has seven goals in the last three matches and nine overall in […]
Deontay Wilder vs. Tyrrell Herndon fight prediction, start time, where to watch, odds, undercard, preview
Once one of the most feared punchers on the planet, Deontay Wilder heads into Friday's fight with Tyrrell Herndon desperately needing to find an offensive spark.Wilder (43-4-1, 42 KO) has lost four of his five most recent trips to the ring, but the past two fights were especially troubling. Wilder was listless in losing a wide 12-round decision to Joseph Parker, landing just 39 of 204 punches thrown. Things got even worse against Zhilei Zhang, when Wilder landed just 16 of 95 punches thrown before suffering a brutal fifth-round knockout. Wilder went undefeated in the first 43 bouts of his pro career, including 41 knockout wins, with the lone blemish a controversial December 2018 draw against Tyson Fury in a fight most felt Fury deserved to win. Fury would prove to be the better man when he won their February […]
Deontay Wilder vs. Tyrrell Herndon fight prediction, start time, where to watch, odds, undercard, preview
Once one of the most feared punchers on the planet, Deontay Wilder heads into Friday's fight with Tyrrell Herndon desperately needing to find an offensive spark.Wilder (43-4-1, 42 KO) has lost four of his five most recent trips to the ring, but the past two fights were especially troubling. Wilder was listless in losing a wide 12-round decision to Joseph Parker, landing just 39 of 204 punches thrown. Things got even worse against Zhilei Zhang, when Wilder landed just 16 of 95 punches thrown before suffering a brutal fifth-round knockout. Wilder went undefeated in the first 43 bouts of his pro career, including 41 knockout wins, with the lone blemish a controversial December 2018 draw against Tyson Fury in a fight most felt Fury deserved to win. Fury would prove to be the better man when he won their February […]
Related
Reserve QBs to start as Redblacks host Argonauts
Jun 6, 2025; Montreal, Quebec, Canada; Toronto Argonauts quarterback Nick Arbuckle (4) throws a pass during the first half against the Montreal Alouettes at Percival-Molson stadium. Mandatory Credit: Eric Bolte-Imagn Images Two squads who have their primary quarterbacks ailing and just one combined victory this season square off Sunday night when the Toronto Argonauts visit the Ottawa Redblacks. On the final injury report of the week, the Argonauts announced that 2023 Most Outstanding Player Chad Kelly will not make his season debut. Kelly broke the tibia and fibula in his right leg last November in the East Final at Montreal and missed the following week's victorious Grey Cup contest over the Winnipeg Blue Bombers. "Definitely not this week, definitely not next week. I'm hoping (Kelly will return) after the bye," Argonauts coach Ryan Dinwiddie told TSN. "He's getting better but […]
Naz Reid agrees to new five-year, $125 million deal to stay with Timberwolves: Report
Naz Reid has signed a new five-year, $125 million contract to stay with the Minnesota Timberwolves, according to ESPN's Sham Charania.Reid had the choice to exercise a $15 million player option to stay with the Timberwolves. Instead, he has agreed to a deal to keep him with Minnesota long-term. Per Charania, the new contract also includes a new player option.After winning the NBA’s Sixth Man of the Year award after a breakout 2023-24 campaign, the 6-foot-9, 264-pound Reid authored an impressive encore, averaging 14.2 points, 6.0 rebounds and 2.3 assists in 27.5 minutes per game, all career highs, as an integral frontcourt contributor for a Wolves team that made its second straight run to the Western Conference finals.The sixth-year pro has turned into one of the NBA’s premier reserves, serving as a high-volume, high-efficiency stretch big who has fit snugly […]
Hosting RSL, Sporting KC out to build on improbable win
Jun 25, 2025; Kansas City, Kansas, USA; Sporting Kansas City forward Dejan Joveljic (9) is carried off the field after getting injured scoring the go ahead goal in the second half against Charlotte FC at Children's Mercy Park. Mandatory Credit: Peter Aiken-Imagn Images Could Wednesday night have been the pivot on which Sporting Kansas City's season turns? Down 1-0 at home in stoppage time against Charlotte FC, Sporting KC scored twice in a four-minute span to turn a near-certain defeat into an exhilarating 2-1 win. The improbable victory gave the team three unexpected points to possibly start a playoff push. Sporting KC will try to build on that dramatic result Saturday night when they face Real Salt Lake in Kansas City, Kan. Interim coach Kerry Zavagnin wasn't surprised that his team figured out a way to win a game that […]
Desperate FC Dallas welcomes surging San Diego FC
Jun 25, 2025; Vancouver, British Columbia, CAN; San Diego FC forward Milan Iloski (32) celebrates scoring during the first half against the Vancouver Whitecaps at BC Place. Mandatory Credit: Anne-Marie Sorvin-Imagn Images San Diego FC looks to strengthen its hold atop the Western Conference and complete the season sweep over FC Dallas when the two teams square off on Saturday in Frisco, Texas. San Diego (11-5-3, 36 points) beat Vancouver 5-3 on Wednesday to leapfrog the host Whitecaps and claim first place in the West. Milan Iloski scored a team-record four goals in his first MLS start -- three in a nine-minute span late in the first half -- as San Diego won for the third straight time in MLS play. Iloski, a 25-year-old native of Escondido, California, has seven goals in the last three matches and nine overall in […]
Deontay Wilder vs. Tyrrell Herndon fight prediction, start time, where to watch, odds, undercard, preview
Once one of the most feared punchers on the planet, Deontay Wilder heads into Friday's fight with Tyrrell Herndon desperately needing to find an offensive spark.Wilder (43-4-1, 42 KO) has lost four of his five most recent trips to the ring, but the past two fights were especially troubling. Wilder was listless in losing a wide 12-round decision to Joseph Parker, landing just 39 of 204 punches thrown. Things got even worse against Zhilei Zhang, when Wilder landed just 16 of 95 punches thrown before suffering a brutal fifth-round knockout. Wilder went undefeated in the first 43 bouts of his pro career, including 41 knockout wins, with the lone blemish a controversial December 2018 draw against Tyson Fury in a fight most felt Fury deserved to win. Fury would prove to be the better man when he won their February […]
Deontay Wilder vs. Tyrrell Herndon fight prediction, start time, where to watch, odds, undercard, preview
Once one of the most feared punchers on the planet, Deontay Wilder heads into Friday's fight with Tyrrell Herndon desperately needing to find an offensive spark.Wilder (43-4-1, 42 KO) has lost four of his five most recent trips to the ring, but the past two fights were especially troubling. Wilder was listless in losing a wide 12-round decision to Joseph Parker, landing just 39 of 204 punches thrown. Things got even worse against Zhilei Zhang, when Wilder landed just 16 of 95 punches thrown before suffering a brutal fifth-round knockout. Wilder went undefeated in the first 43 bouts of his pro career, including 41 knockout wins, with the lone blemish a controversial December 2018 draw against Tyson Fury in a fight most felt Fury deserved to win. Fury would prove to be the better man when he won their February […]
Be the first to leave a comment