The 2025 MLB All-Star Game features the American League and National League matching up on Tuesday. This is the 95th All-Star Game in history, and the AL has won 10 of their last 11 matchups. Last year at Globe Life Field, the American League beat the National League 5-3. Paul Skenes (4-8, 2.01 ERA) will take the mound for the NL, with Tarik Skubal (10-3, 2.23 ERA) getting the start for the AL.
First pitch from Truist Park in Atlanta is set for 8 p.m. ET. Since 1997, the AL has gone is 22-4-1. The NL is a -115 favorite on the money line (risk $115 to win $100) in the latest 2025 MLB All-Star Game odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 7. Before making any American League vs. National League picks, be sure to see the 2025 MLB All-Star Game predictions from SportsLine’s Bruce Marshall, who has returned +1022 on his last 92 MLB picks, making him SportsLine’s No. 1 expert entering the break.
Now, Marshall has set his sights on American League vs. National League. You can visit SportsLine now to see his picks. Here are the MLB odds and betting lines for the MLB All-Star Game 2025, which you can get in on with a DraftKings promo code or a FanDuel promo code. The latest DraftKings promo code will get you $150 in bonus bets instantly, while the latest FanDuel promo code is good for $150 in bonus bets if your first bet wins:
2025 MLB All-Star Game odds
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American League vs. National League money line |
American League -105, National League -115 at DraftKings Sportsbook |
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American League vs. National League over/under |
7.5 runs |
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American League vs. National League run line |
American League -1.5 (+158) |
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American League vs. National League picks |
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American League vs. National League streaming |
Fubo (Try for free) |
Why the National League can win
Chicago Cubs center fielder Pete Crow-Armstrong is making his first All-Star Game appearance after a dominant first half. Crow-Armstrong is tied for sixth in the MLB in home runs (25) and seventh in RBI (71). This campaign, he has recorded 21 doubles and 99 hits for the Cubs. On July 10 against the Twins, he was 3-of-4 with two home runs and three runs driven in.
San Diego Padres third baseman Manny Machado has great power and strength at the plate. The seven-time All-Star has a .292 batting average, 17 dingers and 56 RBI. In Sunday’s game against the Phillies, Machado went 2-of-4 with two singles. See which team to back at SportsLine.
Why the American League can win
Detroit Tigers left fielder Riley Greene is tied for eighth in the league in home runs (24) and tied for third in RBI (78). The 24-year-old is 16th in the majors in OBS (.879) with a .284 batting average. He’s also two-plus hits in two of his last three games, including 2-of-4 with a solo homer.
Yankees outfielder Aaron Judge is a massive difference-maker at the plate. He’s first on the league in batting average (.355) and first in OPS (1.194). In addition, Judge ranks second in the MLB in home runs (35) and RBI (81). On Saturday versus the Cubs, Judge was 3-of-4 with a double, a homer and two RBI. See which team to back at SportsLine. You can bet the AL at Bet365, where you can get $150 in bonus bets with a $5 wager:
How to make 2025 MLB All-Star Game picks
Marshall is leaning Under on the total, and has identified a critical x-factor that has him backing one side. See what it is at SportsLine.
Who wins the 2025 MLB All-Star Game, and what critical x-factor do you need to know about? Visit SportsLine right now to get Marshall’s picks, all from the MLB handicapper who is up $1,022 in his last 92 MLB picks.
This news was originally published on this post .
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