AL Central opponents meet as the Cleveland Guardians travel to play the Chicago White Sox Friday afternoon in Game 1 of a doubleheader. This is a makeup game for Thursday’s contest, which was rained out. The Guardians have played below expectations this season as they enter this matchup at 42-48 overall. They did, however, just sweep the Astros on the road. The White Sox are just 31-62, but have won three of their past six and beat the Blue Jays last time out on Wednesday. Lefty Logan Allen (5-7, 4.07 ERA) is on the hill for Cleveland in Game 1, while righty Shane Smith (3-7, 4.20 ERA) is scheduled to pitch for Chicago.
First pitch for Game 1 from Rate Field is set for 3:10 p.m. ET. Cleveland is a -127 favorite on the money line (risk $127 to win $100) in the latest Guardians vs. White Sox odds, while the total number of runs Vegas thinks will be scored, or the over/under, is 8.5. Before making any White Sox vs. Guardians picks, be sure to see the MLB predictions and betting advice from SportsLine’s proven computer model.
The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 16 of the 2025 MLB season 45-38 on top-rated MLB picks. It has excelled making home run prop picks this season, returning more than 28 units of profit. Anybody following at sportsbooks and on betting apps could have seen strong returns.
Now, the model has set its sights on White Sox vs. Guardians and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model’s picks. Here are several MLB odds and betting lines for Guardians vs. White Sox, which you can get in on with a DraftKings promo code or a FanDuel promo code.
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Guardians vs. White Sox money line |
Chicago +107, Cleveland -127 at DraftKings Sportsbook |
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Guardians vs. White Sox over/under |
8.5 runs |
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Guardians vs. White Sox run line |
New York -1.5 (+129) |
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Guardians vs. White Sox picks |
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Guardians vs. White Sox streaming |
Fubo (Try for free) |
Top White Sox vs. Guardians prop picks
After 10,000 simulations, SportsLine’s top prop pick for Guardians vs. White Sox is Cleveland third baseman Jose Ramirez to go Over 1.5 total bases.
Ramirez has at least one hit in five of his last six games, with three multi-hit games during span. He’s also hit a home run in three straight games, pushing his June OPS to .933 and his slugging percentage to .618 during the month. He has a hit in one of his three at-bats against Smith as well.
SportsLine’s model is projecting 2.2 total bases for Ramirez, making this a 5-star prop pick at -107 on the consensus line. See more picks at SportsLine.
How to make Guardians vs. White Sox picks
In addition, SportsLine’s model is leaning Over on the total, projecting 9.9 combined runs, and it says one side of the money line has all the value. You can head to SportsLine to see the model’s MLB picks.
So who wins White Sox vs. Guardians, and which side of the money line has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.
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