The Week 2 college football schedule may lack the top-10 matchups that last Saturday saw, but it will see two of the winningest programs in the history of the sport colliding. No. 15 Michigan will head to Norman, Okla., to face the 18th-ranked Sooners, with OU 5.5-point favorites per the latest Week 2 college football lines. The two schools rank in the top five, all-time, in college football championships amongst major programs while each is also in the top six in wins. Elsewhere, there are several matchups which feature in-state battles as bragging rights will be on the line.
Iowa vs. Iowa State has been contested since 1894, and the latest installment of the series sees the No. 16 Cyclones as 3.5-point favorites, according to the Week 2 college football odds. There is also No. 3 LSU vs Louisiana Tech (+37.5), No. 13 Florida vs. South Florida (+17.5) and No. 17 SMU vs. Baylor (+3). Meanwhile, Bill Belichick will look for his first UNC victory when his Tar Heels visit Charlotte, with the 49ers 16.5-point underdogs per the college football spreads. Before locking in any Week 2 college football picks, be sure to see the latest Week 2 college football predictions from SportsLine’s proven model.
The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college football spread picks, and was a profitable 27-16 combined on money-line and over/under college football picks in 2024. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns.
Now, it has turned its attention to the latest college football odds and Week 2 college football betting lines on the spread, money line, and over/under. Head here to see every pick, and new users can also target the DraftKings promo code, which offers new users $300 in bonus bets instantly plus over $200 off NFL Sunday Ticket:
Top college football predictions for Week 2
One of the college football picks the model is high on during Week 2: Mississippi State (+6.5) covers at home versus No. 12 Arizona State at 7:30 p.m. ET on Saturday. The Sun Devils are 0-2 all-time on the road versus SEC opponents and 1-6 overall against the conference. While both teams are coming off double-digit victories in Week 1, only Mississippi State covered, and it did it versus a superior opponent in Southern Miss. Meanwhile, Arizona State played an FCS school in Northern Arizona and wasn’t within 10 points of covering the 29.5-point spread.
ASU defeated Mississippi State by just a touchdown when these two played in Tempe, Ariz., last season as the Sun Devils needed a 297-yard game from Cam Skattebo to get the win. However, he’s now in the NFL, and the Bulldogs’ run defense is vastly improved as it held Southern Miss to under 3.0 yards per carry. The Sun Devils are coming off a 12-penalty game in their opener and have to contend with a Bulldogs program which clearly gets up for big games as MSU has covered in four straight versus ranked teams. The model projects Mississippi State to cover over 50% of the time. See which other picks the model likes here.
Another prediction: Syracuse (-6.5) covers versus UConn on Saturday at noon ET. These former Big East rivals have had a one-sided rivalry as of late, with the Orange winning each of the last five meetings. They’ve played four times since 2016, with Syracuse winning all four by at least 7 points and having an average margin of victory of 19.5 points. In last year’s matchup, Cuse diced up Connecticut through the air with season highs in passing yards (470) and completion percentage (78.7) while having zero giveaways.
UConn quarterback Joe Fagnano is in his seventh year of college football and his third at Connecticut, but he’s yet to win a road game versus a Power 4 team. Meanwhile, Cuse QB Steve Angeli, who transferred from Notre Dame, has five touchdowns versus zero interceptions at home in his collegiate career. Look for him to take advantage of a Huskies defense which isn’t the same on the road, as UConn gave up 311.4 passing yards in away games in 2024, compared to 161.1 in home games. The Orange are forecasted to cover well over 50% of the time, with the Over (58.5) hitting in over 50% of simulations. See the rest of the model’s picks here.
How to make college football picks for Week 2
The model has also made the call on who wins and covers in every FBS matchup in Week 2, and it’s calling for a ranked team to be upset in one of the week’s biggest games. You can only get every pick for every game at SportsLine, and for a limited time you can use promo code CHAMPIONSHIP to get your first month at SportsLine for $1.
So what college football picks can you make with confidence, and which underdog wins outright? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $2,000 in profit since its inception, and find out.
Week 2 college football odds for notable games
See full Week 2 college football picks, odds, predictions here
(odds subject to change)
Saturday, Sep. 6
Illinois vs. Duke (+3, 49.5)
Virginia vs. NC State (-2.5, 55.5)
UConn vs. Syracuse (-6.5, 58.5)
Iowa vs. Iowa State (-3, 41.5)
Baylor vs. SMU (-2.5, 65.5)
Ole Miss vs. Kentucky (+10, 50.5)
Oklahoma State vs. Oregon (-28.5, 57.5)
North Carolina vs. Charlotte (+12.5, 49.5)
Army vs. Kansas State (-17, 46.5)
Vanderbilt vs. Virginia Tech (-1.5, 47.5)
Arizona State vs. Mississippi State (+6.5, 59)
Michigan vs. Oklahoma (-5.5, 46)
UCLA vs. UNLV (+2.5, 53.5)
Stanford vs. BYU (-18.5, 46.5)
This news was originally published on this post .
About the author
Alessia Russo signs new long-term Arsenal contract
Alessia Russo has signed a new long-term contract with Arsenal.Russo, 26, has been an important figure for Arsenal since joining the club from Manchester United on a free transfer in July 2023.The England international’s previous terms were due to expire next summer.“Arsenal feels like home,” Russo told Arsenal’s in-house media. “This is such a special club and it has felt that way to me from the moment I joined two years ago. Playing for Arsenal is an honour and has pushed me to develop and grow as a player, and I feel empowered with this badge on my chest.Advertisement“I’m so proud of everything we’ve achieved together as a club, with our supporters driving us forward. But I’m still so hungry for more success, and I know that’s shared by everyone here at the club.”Russo finished the 2024-25 season as the […]
London City Lionesses sign Grace Geyoro from Paris Saint-Germain
London City Lionesses have completed the signing of France midfielder Grace Geyoro from Paris Saint-Germain.The deal represents the latest high-profile transfer by London City, the club controlled by Washington Spirit and Lyon Feminin owner Michele Kang, ahead of their debut season in the Women’s Super League.AdvertisementGeyoro, 28, has spent her entire club career at PSG. The midfielder was a part of PSG’s league title-winning team in 2020-21, as they became the only club other than Lyon to win the Premiere Ligue since 2005-06. She also helped PSG to the Champions League final in 2016-17, and to four semi-finals in subsequent years — the most recent coming in the 2023-24 season.Geyoro played in all four of France’s matches at the European Championships this summer, scoring twice as her side were knocked out by Germany in the quarter-finals. She has been capped […]
Valkyries give Ballhalla a new crescendo to clinch historic playoff spot
SAN FRANCISCO — It was the culmination of a season that has defied reason. The Golden State Valkyries needed one big basket to lock up a playoff spot. One clutch play to make history. A climax for the phenomenon in the Bay Area. The fitting author: Veronica Burton.Burton drove down the right side of the paint and planted her shoulder into the defender, as she so deftly does. She absorbed the bump and went for the tough fall-away shot. The whistle blew. The runner banked in off the glass. The point guard screamed “And-1!” from the depths of her soul.Advertisement“I felt like I blacked out in the moment,” Burton said.And Ballhalla had a new crescendo. A violet eruption.Burton’s 3-point play punctuated an 84-80 win over the Dallas Wings and kicked off a party. On behalf of the team they’ve fallen […]
Daniel Levy’s shock removal by Spurs: Gibb River review, change in Lewis family relations, what it means for sale
The story of Tottenham Hotspur in the 21st century has been the story of the relationship between Daniel Levy, the long-standing chairman, and the Lewis family, the majority shareholders. Levy started working for Joe Lewis as a young man in the 1990s, was widely thought of as Lewis’ protegee, and became the managing director of ENIC, the investment firm who bought 29.9 per cent of Tottenham from Alan Sugar in December 2000 for £22million.AdvertisementLevy became chairman in 2001 and, for 24 years, he ran Tottenham with a firm grip, as the club grew into a huge global brand, valued at roughly £4billion ($5.4bn), playing in one of the best new stadiums in Europe. The Lewis family were content to stay in the background, as Levy became the public face of the club.But on Thursday September 4, that working relationship, the […]
Prescott denies spitting first as Carter apologises after dramatic NFL opener
Jalen Carter apologised to his teammates while Dak Prescott pleaded his innocence after the Philadelphia Eagles star was ejected for spitting on the Dallas Cowboys quarterback in Thursday night's NFL season opener.Eagles defensive tackle Carter was ejected just six seconds into his side's 24-20 victory when he spat on Prescott in front of an official during a verbal exchange between the pair. Footage later appeared to show Prescott spitting in the direction of Carter from a distance first, though he later denied he was intending to spit at his opponent. Please use Chrome browser for a more accessible video player Highlights from the Dallas Cowboys at the Philadelphia Eagles in Week One of the NFL season "I probably spit about 1,000 times throughout the game, especially gameday, maybe general," said Prescott. "In that case he was trolling, trying to mess […]
Steve Ballmer denies allegations of Kawhi Leonard, Clippers circumventing salary cap
LA Clippers chairman Steve Ballmer denied that his team had circumvented the NBA’s salary-cap rules in an ESPN interview Thursday night, offering a direct response to a report by the “Pablo Torre Finds Out” podcast. He also said he welcomed the league’s investigation into the arrangements.Ballmer sat down with ESPN reporter Ramona Shelburne for a 16-minute interview and said he did not know anything about star forward Kawhi Leonard’s reported endorsement deal with Aspiration, a now-bankrupt environmental company the Clippers signed a massive sponsorship deal with in 2021. Ballmer added that Leonard’s 2021 contract with the Clippers was not related to the team’s association with Aspiration and that the Clippers “have abided by the salary-cap circumvention rules because that’s the right thing to do.”Advertisement“Pablo’s podcast, I don’t know anything about the court documents on this,” Ballmer said Thursday night. “I […]
Related
Alessia Russo signs new long-term Arsenal contract
Alessia Russo has signed a new long-term contract with Arsenal.Russo, 26, has been an important figure for Arsenal since joining the club from Manchester United on a free transfer in July 2023.The England international’s previous terms were due to expire next summer.“Arsenal feels like home,” Russo told Arsenal’s in-house media. “This is such a special club and it has felt that way to me from the moment I joined two years ago. Playing for Arsenal is an honour and has pushed me to develop and grow as a player, and I feel empowered with this badge on my chest.Advertisement“I’m so proud of everything we’ve achieved together as a club, with our supporters driving us forward. But I’m still so hungry for more success, and I know that’s shared by everyone here at the club.”Russo finished the 2024-25 season as the […]
London City Lionesses sign Grace Geyoro from Paris Saint-Germain
London City Lionesses have completed the signing of France midfielder Grace Geyoro from Paris Saint-Germain.The deal represents the latest high-profile transfer by London City, the club controlled by Washington Spirit and Lyon Feminin owner Michele Kang, ahead of their debut season in the Women’s Super League.AdvertisementGeyoro, 28, has spent her entire club career at PSG. The midfielder was a part of PSG’s league title-winning team in 2020-21, as they became the only club other than Lyon to win the Premiere Ligue since 2005-06. She also helped PSG to the Champions League final in 2016-17, and to four semi-finals in subsequent years — the most recent coming in the 2023-24 season.Geyoro played in all four of France’s matches at the European Championships this summer, scoring twice as her side were knocked out by Germany in the quarter-finals. She has been capped […]
Valkyries give Ballhalla a new crescendo to clinch historic playoff spot
SAN FRANCISCO — It was the culmination of a season that has defied reason. The Golden State Valkyries needed one big basket to lock up a playoff spot. One clutch play to make history. A climax for the phenomenon in the Bay Area. The fitting author: Veronica Burton.Burton drove down the right side of the paint and planted her shoulder into the defender, as she so deftly does. She absorbed the bump and went for the tough fall-away shot. The whistle blew. The runner banked in off the glass. The point guard screamed “And-1!” from the depths of her soul.Advertisement“I felt like I blacked out in the moment,” Burton said.And Ballhalla had a new crescendo. A violet eruption.Burton’s 3-point play punctuated an 84-80 win over the Dallas Wings and kicked off a party. On behalf of the team they’ve fallen […]
Daniel Levy’s shock removal by Spurs: Gibb River review, change in Lewis family relations, what it means for sale
The story of Tottenham Hotspur in the 21st century has been the story of the relationship between Daniel Levy, the long-standing chairman, and the Lewis family, the majority shareholders. Levy started working for Joe Lewis as a young man in the 1990s, was widely thought of as Lewis’ protegee, and became the managing director of ENIC, the investment firm who bought 29.9 per cent of Tottenham from Alan Sugar in December 2000 for £22million.AdvertisementLevy became chairman in 2001 and, for 24 years, he ran Tottenham with a firm grip, as the club grew into a huge global brand, valued at roughly £4billion ($5.4bn), playing in one of the best new stadiums in Europe. The Lewis family were content to stay in the background, as Levy became the public face of the club.But on Thursday September 4, that working relationship, the […]
Prescott denies spitting first as Carter apologises after dramatic NFL opener
Jalen Carter apologised to his teammates while Dak Prescott pleaded his innocence after the Philadelphia Eagles star was ejected for spitting on the Dallas Cowboys quarterback in Thursday night's NFL season opener.Eagles defensive tackle Carter was ejected just six seconds into his side's 24-20 victory when he spat on Prescott in front of an official during a verbal exchange between the pair. Footage later appeared to show Prescott spitting in the direction of Carter from a distance first, though he later denied he was intending to spit at his opponent. Please use Chrome browser for a more accessible video player Highlights from the Dallas Cowboys at the Philadelphia Eagles in Week One of the NFL season "I probably spit about 1,000 times throughout the game, especially gameday, maybe general," said Prescott. "In that case he was trolling, trying to mess […]
Steve Ballmer denies allegations of Kawhi Leonard, Clippers circumventing salary cap
LA Clippers chairman Steve Ballmer denied that his team had circumvented the NBA’s salary-cap rules in an ESPN interview Thursday night, offering a direct response to a report by the “Pablo Torre Finds Out” podcast. He also said he welcomed the league’s investigation into the arrangements.Ballmer sat down with ESPN reporter Ramona Shelburne for a 16-minute interview and said he did not know anything about star forward Kawhi Leonard’s reported endorsement deal with Aspiration, a now-bankrupt environmental company the Clippers signed a massive sponsorship deal with in 2021. Ballmer added that Leonard’s 2021 contract with the Clippers was not related to the team’s association with Aspiration and that the Clippers “have abided by the salary-cap circumvention rules because that’s the right thing to do.”Advertisement“Pablo’s podcast, I don’t know anything about the court documents on this,” Ballmer said Thursday night. “I […]
Be the first to leave a comment