Penn State vs. UCLA prediction, odds, spread, time: 2025 Week 6 college football picks by proven model

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A Big Ten showdown features Drew Allar and the No. 7 Penn State Nittany Lions (3-1) and Nico Iamaleava and the UCLA Bruins (0-4) matching up on Saturday. Last weekend, PSU fell 30-24 to Oregon in a double overtime tilt. Meanwhile, UCLA is still winless this season and is playing under interim head coach Tim Skipper. On Sept. 27, Northwestern beat the Bruins 17-14, though UCLA did cover for the first time this season in that loss. Penn State defeated UCLA 27-11 in their previous outing last season. 

Kickoff from Rose Bowl in Pasadena, CA is set for 3:30 ET. The Nittany Lions are 24.5-point favorites in the latest Penn State vs. UCLA odds, and the over/under for total points scored is 48.5. Before making any Penn State vs. UCLA picks, be sure to see what the SportsLine projection model has to say. Be sure to watch this game on CBS or Paramount+, where new users can get a free one-week trial. Sign up here.  

New users can also target the DraftKings promo code, which offers $200 in bonus bets instantly if your initial $5 bet wins:

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 37-24 combined on money-line and over/under college football picks since the beginning of 2024. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns.  

Now, the model has zeroed in on Penn State vs. UCLAYou can head to SportsLine now to see its picks. Here are several college football odds and betting lines for Penn State vs. UCLA in Week 6:

Penn State vs. UCLA spread

Nittany Lions -24.5 at DraftKings Sportsbook

Penn State vs. UCLA over/under

48.5 points

Penn State vs. UCLA money line 

Nittany Lions -2400, Bruins +1200

Penn State vs. UCLA picks

See picks at SportsLine

Penn State vs. UCLA streaming 

Paramount+ (Get a free 7-day trial)

Why Penn State can cover

Penn State senior quarterback Drew Allar is completing 62% of his throws for 763 passing yards and six touchdowns. Last season against UCLA, Allar went 17-of-24 for 237 passing yards and a passing touchdown. Senior running back Kaytron Allen has a team-high 327 rushing yards with four rushing scores and 7.1 yards per game. Senior running back Nicholas Singleton is another playmaker in the backfield, as he’s logged 200 rushing yards and a team-high five rushing touchdowns. See which team to back at SportsLine

Why UCLA can cover

Sophomore quarterback Nico Iamaleava is a dual-threat playmaker. He has 788 passing yards and four passing touchdowns. The California native also leads the team in rushing yards (204) with another rushing score. Sophomore receiver Kwazi Gilmer has team highs in catches (19) and receiving yards (225). He has gone over 50 receiving yards in three straight games. See which team to back at SportsLine

New users can also check out the latest FanDuel promo code and get $300 in bonus bets instantly at FanDuel if your $5 bet wins

How to make Penn State vs. UCLA picks

For Penn State vs. UCLA in Week 6, the model is leaning under the total, and also says one side of the spread hits in well over 50% of simulations. See what it is at SportsLine.

Who wins Penn State vs. UCLA, and which side of the spread has all the value? Visit SportsLine now to see which side of the Penn State vs. UCLA spread you need to jump, all from the model that is a combined 37-24 on top-rated picks since 2024, and find out.

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