Nate Tice & Charles McDonald dive into the Week 6 NFL slate with bold predictions, matchups to watch and more. The two hosts kick things off by getting Lost in the Sauce with their three favorite games – San Francisco 49ers vs. Tampa Bay Buccaneers, Detroit Lions vs. Kansas City Chiefs & Chicago Bears vs. Washington Commanders – analyzing what to watch for on each side of the ball, key matchups and final predictions.
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Later, Nate & Charles bust out the Cheat Sheet, where they each give one thing to watch in the Seattle Seahawks vs. Jacksonville Jaguars matchup and the Buffalo Bills taking on the Atlanta Falcons on Monday.
Finally, the duo give their Hail Mary bold predictions for the weekend, as Charles reluctantly backs the Cleveland Browns against the Pittsburgh Steelers and Nate picks the New York Jets to pull off a huge upset against the Denver Broncos in London.
(2:40) – 49ers @ Buccaneers preview
(20:55) – Lions @ Chiefs preview
(39:15) – Bears @ Commanders preview
(52:30) – Cheat Sheet: SEA @ JAX and BUF @ ATL
(1:03:15) – Hail Mary bold predictions!
KANSAS CITY, MISSOURI – SEPTEMBER 28: Patrick Mahomes #15 of the Kansas City Chiefs reacts prior to an NFL football game against the Baltimore Ravens at GEHA Field at Arrowhead Stadium on September 28, 2025 in Kansas City, Missouri. (Photo by Michael Owens/Getty Images)
(Photo by Michael Owens/Getty Images)
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