There are several interesting quarterback matchups on Sunday that could add some spice to your Week 5 NFL picks. Quarterbacks who’ve had more success since leaving New York, in Geno Smith and Daniel Jones, meet in Raiders vs. Colts (-7). Former Alabama signal callers in Tua Tagovailoa and Bryce Young square off in Dolphins vs. Panthers (+1.5), while No. 1 picks in Cam Ward and Kyler Murray meet in Titans vs. Cardinals (-7.5). Not only can you target these games with Week 5 NFL bets, but the respective QBs can be used as NFL DFS picks, in Week 5 Fantasy football lineups, or in NFL player props.
A Week 5 NFL betting guide would help identify the NFL lines to target with your picks, either for these matchups or others. Nine games have a spread of 3.5 points or fewer, per the latest Week 5 NFL odds, which could be a plus or a negative to football bettors. Whether you prefer targeting narrow spreads or wide ones, your Week 5 NFL betting strategy should leave no stone unturned.
If you are looking for NFL picks, NFL parlays, Fantasy football rankings or NFL DFS picks for Week 5, SportsLine has you covered with its proven model, Machine Learning Model and team of experts. Join SportsLine here, and for a limited time get your first month for $1 using promo code CHAMPIONSHIP.
NFL parlay picks could generate massive payouts
SportsLine’s model has returned well over $7,000 on top-rated NFL betting picks since its inception, so those picks can confidently be used to fill out NFL parlay picks on betting apps. The model has built a five-team parlay for Week 5 that pays 25-1, and one of the legs is the Minnesota Vikings (-3.5, 36.5) covering against the Browns in London. The model has Minnesota covering in almost 60% of simulations, and the rest of the five-team parlay can be found here.
NFL DFS picks from top experts
SportsLine has a DFS Optimizer that simulates every game 10,000 times and uses info from the SportsLine Projection Model and DFS Professional Millionaire Mike McClure to identify top DFS picks/plays for any slate on sites like FanDuel and DraftKings. It has the Jets’ Garrett Wilson as one of its top value picks at receiver, while Miami’s Darren Waller is among the best values at tight end for Sunday’s main slate. Here are its complete Week 5 NFL DFS rankings.
Senior Fantasy Writer Heath Cummings has locked in his projections for every Fantasy relevant quarterback, running back, wide receiver and tight end in your leagues. Not only do you get statistical projections as well as Fantasy point totals for every player in different scoring formats, but Cummings also includes DFS prices and values to help build winning DFS lineups each week. Get his Week 5 Fantasy and DFS projections right here. You can also make NFL prop bets on Wilson, Waller and others with the Underdog Fantasy promo code CBSSPORTS2.
Pick at Underdog Fantasy and get $100 in site credits after making a $5 wager:
Fantasy rankings to help you win your matchups
SportsLine’s model simulates every game 10,000 times, which has helped it produce better Fantasy rankings than human experts over the last few seasons. It has revealed its Week 5 Fantasy football rankings that can be used to make start-sit decisions. Indianapolis’ Daniel Jones is projected to be a top-5 Fantasy quarterback this week, and the model also has full rankings for every position right here.
Advanced NFL model simulates every game 10,000 times
SportsLine’s model enters Week 5 of the 2025 NFL season up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 39-19 run on top-rated picks dating back to 2024 and has revealed picks for every Week 5 NFL game. One of its favorite picks is the Saints (-1.5) covering at home versus the Giants, which cashes 60% of the time. You can find the model’s picks for every NFL Week 5 game here.
You can also use the latest FanDuel promo code to get $300 in bonus bets instantly:
NFL Vegas expert picks revealed
SportsLine has an expansive team of NFL experts who provide quality betting advice for every game on the schedule. Analyst Todd Fuhrman, who is on an 8-2 roll (+593) over his last 10 NFL picks, has revealed his best bets for Week 5. He is backing the Texans (+1.5) to cover on the road versus the Ravens. Fuhrman’s NFL best bets for Week 5 can be found here.
Eric Cohen, who is 44-19-1 (70%) on his straight-up NFL picks this season, has exact score predictions for all 14 games. He is high on the Chargers (-2.5, 47.5) to defeat the Commanders, 29-23, on Sunday. Hit any of his exact score picks and you’re looking at a payout well over 100-1. That pick, along with his prediction for every game, is available here.
Pick using the BetMGM bonus code CBSSPORTS, which offers new users up to $1,500 back in bonus bets if your first bet loses:
Bills vs. Patriots ‘Sunday Night Football’ picks
The only divisional matchup on Sunday will take place on SNF as the Bills host the Patriots. The last four meetings between these teams have all been decided by seven or fewer points, while the Bills have won 14 straight home games. SportsLine’s model likes the Over (49.5) to hit in nearly 60% of simulations, projecting 53 combined points. It also has revealed an A-rated spread pick that hits in over 70% of simulations. See Patriots vs. Bills picks from the SportsLine advanced model here.
Chiefs vs. Jaguars ‘Monday Night Football’ picks
The Chiefs will seek their ninth straight win over the Jaguars on Monday night, with the turnover battle likely playing a big role in the result. No team has more takeaways than the Jaguars 13 this season, while no team has turned the ball over fewer times than the Chiefs’ one giveaway. SportsLine’s model likes the Chiefs (-3.5) to cover in well over 50% of simulations. It also projects one team to allow a touchdown more than what it’s given up on average in 2025, while another team doesn’t have a single player reach 50 receiving yards. See Chiefs vs. Jags predictions from the model here.
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