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Another NFC West rivalry kicks off on Thursday Night Football. The Los Angeles Rams (3-1) host the San Francisco 49ers (3-1), each team trying to get the upper hand in the division.
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The connection between Puka Nacua and Matthew Stafford has been off to a fast start this season. Nacua leads the NFL in receptions (42) and yards (503) through four weeks. Last week, Nacua caught 13 passes and a career-high 170 yards and a touchdown.
Stafford is second in the NFL in passing yards (1,114), averaging 278.5 through four games. The 49ers’ defense is allowing just 165 passing yards per game against opposing quarterbacks, good for sixth-best in the league.
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5 Things to Know
- San Francisco’s defense is 6th in passing defense.
- The Rams are on a three-game win streak against the 49ers.
- Niners WR Ricky Pearsall is fourth in the NFL with 327 yards.
- Pearsall and RB Christian McCaffrey (305) are the only teammates in the top 10 in receiving yards.
- Rams RB, Kyren Williams, is seventh in the league in rushing yards with 303.
Los Angeles Betting Info
- Los Angeles has played four games, posting three wins against the spread.
- Los Angeles games this year have gone over the total in two out of four opportunities (50%).
- The Rams have won each of the three games they were the moneyline favorite this season.
- The Rams have an implied win probability, based on the moneyline, of 77.3%.
San Francisco Betting Info
- San Francisco has covered the spread two times in four games with a set total.
- Games involving San Francisco have hit the over twice this year.
- The 49ers have not played a game this season while listed as the underdog.
- The sportsbooks’ moneyline implies a 27.0% chance of a victory for the 49ers.
Los Angeles’ Key Players
- Matthew Stafford is second in the NFL with 1,114 passing yards through four games this year, averaging 278.5 per game with a 67.6% completion percentage and eight touchdowns (third in the NFL) and only two interceptions.
- Puka Nacua has caught 42 passes (first in the NFL) on 50 targets for 503 total yards (first in the NFL) and one touchdown. He is averaging 10.5 catches and 125.8 yards per game in four games.
- Kyren Williams‘ output on the ground this season includes 303 yards (seventh in the NFL) and one TD. He’s averaging 75.8 yards a game and 4.5 an attempt (20th in the NFL). In the air, he has eight receptions on 11 targets for 52 yards, with one receiving TD.
- Davante Adams has 269 receiving yards and three touchdowns (eighth in the NFL) with 17 catches on 35 targets. He’s averaging 4.3 receptions and 67.3 yards per game.
- Byron Young has racked up 23 tackles, seven TFL, and five sacks in 2025.
- Jared Verse has collected 17 tackles, three TFL, and two sacks this year.
San Francisco’s Key Players
- Christian McCaffrey has not scored a rushing touchdown this year, but has accumulated 225 total rushing yards (56.3 per game and 3.3 per attempt).
- McCaffrey has also been a part of the passing game with 305 yards (76.3 per game) on 31 receptions (7.8 per game), while being targeted 43 times. He has two receiving touchdowns.
- Mac Jones has 563 passing yards, four touchdowns and one interception. His completion percentage is 66.3% and averaging 281.5 yards per game and 7 per attempt.
- In two games this season, Brock Purdy has racked up 586 passing yards, with four touchdowns to go with four interceptions and completing 65.8% of his passes.
- Ricky Pearsall has 327 receiving yards (fourth in the NFL) from 20 receptions after receiving 29 targets.
- Fred Warner has 38 tackles and two TFL in four games. He leads the 49ers and is seventh in the NFL in tackles.
- Bryce Huff has two sacks (first on the 49ers) to go with three TFL and 11 tackles over four games.
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