The Indianapolis Colts (4-1) look to stay hot at home as they host the Arizona Cardinals (2-3) in NFL Week 6. Daniel Jones and the Colts got back into the win column in Week 5 with a decisive 40-6 victory against the visiting Las Vegas Raiders. Meanwhile, Kyler Murray and the Cardinals suffered a second-half meltdown their last time out that resulted in a 22-21 loss to the Tennessee Titans.
Kickoff from Lucas Oil Stadium is set for 1 p.m. ET. Indianapolis is a 6.5-point favorite in the latest Cardinals vs. Colts odds from SportsLine consensus, while the over/under for total points scored is 47.5. The Colts are -300 money line favorites (risk $300 to win $100), while the Cardinals are +231 underdogs. Before making any Colts vs. Cardinals picks, make sure you check out the picks from the SportsLine Projection Model.
Click here to bet Cardinals vs. Colts at DraftKings Sportsbook, where new users get $200 in bonus bets if your initial $5 bet wins:
Where to bet on Colts vs. Cardinals
Where to watch Cardinals vs. Colts on Sunday
When: Sunday, Oct. 12
Time: 1 p.m. ET
TV: FOX
Stream: Fubo
Follow along: CBS Sports App
Colts vs. Cardinals betting preview
Odds: Colts -6.5, over/under 47.5
Arizona was inconsistent as it gave up a 15-point lead and allowed a winless Titans team to get their first victory of the season. Murray ran the ball into the end zone in the first quarter but was held without a touchdown pass on the day. Then, safety Dadrion Taylor-Demerson picked off Cam Ward but fumbled the ball, leaving room for Tyler Lockett to recover it for a Titans touchdown. Now the injuries are piling up on offense including a foot injury Murray sustained against Tennessee, which could make the Cardinals more vulnerable against an opportunistic Indianapolis team.
The Colts were brought back down to earth by their Week 4 loss to the Rams, but were able to coast to victory against the subpar Raiders. Jonathan Taylor had three touchdowns in Week 5 and now leads the league in rushing yards (480) and touchdowns (6). The defense is giving up 315.0 total yards per game but only allowing 17.8 points, so the Colts should have their work cut out for them against a banged-up Cardinals offense.
Click here to bet Cardinals vs. Colts at FanDuel Sportsbook, where new users get $300 in bonus bets if their first bet of at least $5 wins:
Model’s Cardinals vs. Colts score prediction, picks
The Cardinals are 6-2 ATS in their last eight games against the AFC South but are 2-3-0 ATS on the season, while the Colts are 4-1-0 ATS. Even if Murray plays on Sunday, Arizona is inconsistent and a hard bet to back. The SportsLine model projects Indianapolis will cover the spread in 57% of simulations. Cardinals vs. Colts score prediction: Colts 31, Cardinals 21
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