Making NFL picks always carries a bit more excitement when there’s something on the line, and that’s the case with the Week 17 NFL schedule. No less than half a dozen matchups carry postseason implications for both teams, making them ideal ones to target with Week 17 NFL bets. Among those are Texans vs. Chargers (-1.5 at DraftKings Sportsbook) and Ravens vs. Packers (-3) on Saturday, then Jaguars vs. Colts (+6.5), Seahawks vs. Panthers (+7) and Eagles vs. Bills (-1) on Sunday afternoon.
Then on Sunday night, the 49ers are 3-point home favorites over the Bears, per the Week 17 NFL odds. If a rest edge matters to you, then you may want to back the Bears with Week 17 NFL predictions as Chicago’s coming off a Saturday game, while San Fran is coming off a Monday game. All of the updated Week 17 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 17 NFL picks now.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 17 on a 52-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.
Now, it has turned its attention to the latest Week 17 NFL odds and NFL betting lines and locked in betting picks for every NFL matchup. Head here to see every pick.
Top Week 17 NFL predictions
We can tell you one of the model’s strongest Week 17 NFL picks is that the Steelers (-3, 33.5) cover versus Cleveland on Sunday at 1 p.m. ET. Pittsburgh has rolled off three straight wins — and three straight covers — to control its own destiny to claim the AFC North. Meanwhile, Cleveland fought valiantly in its loss to the Bills on Sunday, but the Browns are now 0-4 straight-up and 1-3 ATS over the last month. Shedeur Sanders has brought excitement to the Browns but not necessarily many winning plays as no player has more turnovers (seven) than Sanders since he became starter in Week 12. Pittsburgh capitalizes off taking the ball away as the Steelers have covered in six straight games this season when winning the turnover battle. The model has Pittsburgh prevailing versus the spread nearly 60% of the time. See which other teams to pick here, and bet the Steelers using the DraftKings promo code, which offers $200 in bonus bets if your bet wins right here:
Another one of its Week 17 NFL predictions: the Bengals (-7, 53.5) cover against the Cardinals in a 1 p.m. ET kick on Sunday. Both teams are out of the playoff picture, but Cincinnati is in much better form overall. The Bengals have won two of their past four and have covered in four of their past five. The Cardinals, meanwhile, have dropped seven straight and are just 1-6 against the spread during that span. In addition to backing the Broncos, the model also says the Over hits nearly 60% of the time. See which other teams to pick here, and bet the Bengals to cover at DraftKings:
How to make Week 17 NFL picks
The model has also made the call on who wins and covers in every other game on the Week 17 NFL schedule and just revealed seven teams that outright win nearly 70% of the time, or more, potentially giving you a huge payday. You can only get every pick for every game at SportsLine.
So what Week 17 NFL picks can you make with confidence, and which seven picks should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000, and find out.
Week 17 NFL betting odds, lines, live spreads, scores
Get Week 17 NFL picks at SportsLine
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